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ABSTRACT:
SUBMITTER: Chatkewitz LE
PROVIDER: S-EPMC5761740 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chatkewitz Lindsay E LE Halonski John F JF Padilla Marshall S MS Young Douglas D DD
Bioorganic & medicinal chemistry letters 20171206 2
The prevalence of 1,3-dipolar cycloadditions of azides and alkynes within both biology and chemistry highlights the utility of these reactions. However, the use of a copper catalyst can be prohibitive to some applications. Consequently, we have optimized a copper-free microwave-assisted reaction to alleviate the necessity for the copper catalyst. A small array of triazoles was prepared to examine the scope of this approach, and the methodology was translated to a protein context through the use ...[more]