Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC3079562 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Zhang Qi Q Li Yuxue Y Chen Dandan D Yu Yi Y Duan Lian L Shen Ben B Liu Wen W
Nature chemical biology 20110116 3
The radical S-adenosylmethionine (S-AdoMet) superfamily contains thousands of proteins that catalyze highly diverse conversions, most of which are poorly understood, owing to a lack of information regarding chemical products and radical-dependent transformations. We here report that NosL, involved in forming the indole side ring of the thiopeptide nosiheptide (NOS), is a radical S-AdoMet 3-methyl-2-indolic acid (MIA) synthase. NosL catalyzed an unprecedented carbon chain reconstitution of L-tryp ...[more]