Ontology highlight
ABSTRACT:
SUBMITTER: Yamazaki S
PROVIDER: S-EPMC3080372 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Yamazaki Sayuri S Okada Kohei K Maruyama Akira A Matsumoto Misako M Yagita Hideo H Seya Tsukasa T
PloS one 20110420 4
16 S-[2,3-bis(palmitoyl)propyl]cysteine (Pam2) lipopeptides act as toll-like receptor (TLR)2/6 ligands and activate natural killer (NK) cells and dendritic cells (DCs) to produce inflammatory cytokines and cytotoxic NK activity in vitro. However, in this study, we found that systemic injection of Pam2 lipopeptides was not effective for the suppression of NK-sensitive B16 melanomas in vivo. When we investigated the immune suppressive mechanisms, systemic injection of Pam2 lipopeptides induced IL- ...[more]