Ontology highlight
ABSTRACT:
SUBMITTER: Xie X
PROVIDER: S-EPMC3081021 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Xie Xiaoduo X Zhang Denghong D Zhao Bin B Lu Min-Kan MK You Ming M Condorelli Gianluigi G Wang Cun-Yu CY Guan Kun-Liang KL
Proceedings of the National Academy of Sciences of the United States of America 20110404 16
AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and the hydrophobic motif (S473) by the mammalian target of rapamycin complex 2 (mTORC2). We recently observed that phosphorylation of the AKT hydrophobic motif was dramatically elevated, rather than decreased, in mTOR knockout heart tissues, indicating the existence of other kinase(s) contributing to AKT phosphorylation. Here we show that the atypical IκB kinase ε and TA ...[more]