Ontology highlight
ABSTRACT:
SUBMITTER: Reiley W
PROVIDER: S-EPMC1087725 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Reiley William W Zhang Minying M Wu Xuefeng X Granger Erica E Sun Shao-Cong SC
Molecular and cellular biology 20050501 10
Tumor suppressor CYLD is a deubiquitinating enzyme (DUB) that inhibits the ubiquitination of key signaling molecules, including tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2). However, how the function of CYLD is regulated remains unknown. Here we provide evidence that inducible phosphorylation of CYLD is an important mechanism of its regulation. Under normal conditions, CYLD dominantly suppresses the ubiquitination of TRAF2. In response to cellular stimuli, CYLD undergoes rapi ...[more]