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ABSTRACT:
SUBMITTER: Fleishman SJ
PROVIDER: S-EPMC3081553 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Fleishman Sarel J SJ Khare Sagar D SD Koga Nobuyasu N Baker David D
Protein science : a publication of the Protein Society 20110401 4
Protein-design methodology can now generate models of protein structures and interfaces with computed energies in the range of those of naturally occurring structures. Comparison of the properties of native structures and complexes to isoenergetic design models can provide insight into the properties of the former that reflect selection pressure for factors beyond the energy of the native state. We report here that sidechains in native structures and interfaces are significantly more constrained ...[more]