The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides.
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ABSTRACT:
SUBMITTER: Yamamoto M
PROVIDER: S-EPMC3081973 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides.
Yamamoto Masaki M Sato Takashi T Beren Joel J Verthelyi Daniela D Klinman Dennis M DM
Biomaterials 20110321 18
The process of wound healing involves complex interactions between circulating immune cells and local epithelial and endothelial cells. Studies in murine models indicate that cells of the innate immune system activated via their Toll-like receptors (TLR) can accelerate wound healing. This work examines whether immunostimulatory CpG oligodeoxynucleotides (ODN) designed to trigger human immune cells via TLR9 can promote the healing of excisional skin biopsies in rhesus macaques. Results indicate t ...[more]
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