Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi A
PROVIDER: S-EPMC3082302 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Kobayashi Akio A Stewart C Allison CA Wang Ying Y Fujioka Kaoru K Thomas Nicholas C NC Jamin Soazik P SP Behringer Richard R RR
Development (Cambridge, England) 20110413 10
During male sexual differentiation, the transforming growth factor-β (TGF-β) signaling molecule anti-Müllerian hormone (AMH; also known as Müllerian inhibiting substance, MIS) is secreted by the fetal testes and induces regression of the Müllerian ducts, the primordia of the female reproductive tract organs. Currently, the molecular identity of downstream events regulated by the AMH signaling pathway remains unclear. We found that male-specific Wnt4 expression in mouse Müllerian duct mesenchyme ...[more]