Ontology highlight
ABSTRACT:
SUBMITTER: Noutel J
PROVIDER: S-EPMC3082316 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Neuron 20110401 1
Mutations in MECP2 underlie the neurodevelopmental disorder Rett syndrome (RTT). One hallmark of RTT is relatively normal development followed by a later onset of symptoms. Growing evidence suggests an etiology of disrupted synaptic function, yet it is unclear how these abnormalities explain the clinical presentation of RTT. Here we investigate synapse maturation in Mecp2-deficient mice at a circuit with distinct developmental phases: the retinogeniculate synapse. We find that synapse developmen ...[more]