Ontology highlight
ABSTRACT:
SUBMITTER: Sasai Y
PROVIDER: S-EPMC3082463 | biostudies-literature | 1994 Dec
REPOSITORIES: biostudies-literature
Sasai Y Y Lu B B Steinbeisser H H Geissert D D Gont L K LK De Robertis E M EM
Cell 19941201 5
A Xenopus gene whose expression can be activated by the organizer-specific homeobox genes goosecoid and Xnot2 was isolated by differential screening. The chordin gene encodes a novel protein of 941 amino acids that has a signal sequence and four Cys-rich domains. The expression of chordin starts in Spemann's organizer subsequent to that of goosecoid, and its induction by activin requires de novo protein synthesis. Microinjection of chordin mRNA induces twinned axes and can completely rescue axia ...[more]