Ontology highlight
ABSTRACT:
SUBMITTER: Andreu P
PROVIDER: S-EPMC3082507 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Andreu Pauline P Johansson Magnus M Affara Nesrine I NI Pucci Ferdinando F Tan Tingting T Junankar Simon S Korets Lidiya L Lam Julia J Tawfik David D DeNardo David G DG Naldini Luigi L de Visser Karin E KE De Palma Michele M Coussens Lisa M LM
Cancer cell 20100204 2
Chronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesis, we report that B cells and humoral immunity foster cancer development by activating Fcgamma receptors (FcgammaRs) on resident and recruited myeloid cells. Stromal accumulation of autoantibodies in premalign ...[more]