Ontology highlight
ABSTRACT:
SUBMITTER: Lazaridis I
PROVIDER: S-EPMC3082517 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Lazaridis Iakovos I Charalampopoulos Ioannis I Alexaki Vassilia-Ismini VI Avlonitis Nicolaos N Pediaditakis Iosif I Efstathopoulos Paschalis P Calogeropoulou Theodora T Castanas Elias E Gravanis Achille A
PLoS biology 20110426 4
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival TrkA and pro-death p75(NTR) membrane receptors of neurotrophin nerve growth factor (NGF), acting as a neurotrophic factor: (1) the anti-apoptotic effects of DHEA were reversed by siRNA against TrkA or by a specific TrkA inhibitor; (2) [(3)H]-DHE ...[more]