Ontology highlight
ABSTRACT:
SUBMITTER: Eckhardt F
PROVIDER: S-EPMC3082778 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20061029 12
DNA methylation is the most stable type of epigenetic modification modulating the transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report high-resolution methylation profiles of human chromosomes 6, 20 and 22, providing a resource of about 1.9 million CpG methylation values derived from 12 different tissues. Analysis of six annotation categories showed that evolutionarily conserved regions are the predominant sites for differential DNA methylation and that a co ...[more]