Ontology highlight
ABSTRACT:
SUBMITTER: Bohm V
PROVIDER: S-EPMC3082900 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Böhm Vera V Hieb Aaron R AR Andrews Andrew J AJ Gansen Alexander A Rocker Andrea A Tóth Katalin K Luger Karolin K Langowski Jörg J
Nucleic acids research 20101221 8
Nucleosomes are multi-component macromolecular assemblies which present a formidable obstacle to enzymatic activities that require access to the DNA, e.g. DNA and RNA polymerases. The mechanism and pathway(s) by which nucleosomes disassemble to allow DNA access are not well understood. Here we present evidence from single molecule FRET experiments for a previously uncharacterized intermediate structural state before H2A-H2B dimer release, which is characterized by an increased distance between H ...[more]