Ontology highlight
ABSTRACT:
SUBMITTER: Poortinga G
PROVIDER: S-EPMC3082905 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Poortinga Gretchen G Wall Meaghan M Sanij Elaine E Siwicki Kasia K Ellul Jason J Brown Daniel D Holloway Timothy P TP Hannan Ross D RD McArthur Grant A GA
Nucleic acids research 20101221 8
Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion of the MYC target gene upstream binding factor (UBF) and a switch from epigenetically active to silent rDNA accompanies this MYC reduction. We hypothesized that MYC may coordinate these mechanisms via direct regulation of multiple components of t ...[more]