Ontology highlight
ABSTRACT:
SUBMITTER: Xi Y
PROVIDER: S-EPMC3083088 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Xi Yuanxin Y Yao Jianhui J Chen Rui R Li Wei W He Xiangwei X
Genome research 20110301 5
The structural complexity of nucleosomes underlies their functional versatility. Here we report a new type of complexity-nucleosome fragility, manifested as high sensitivity to micrococcal nuclease, in contrast to the common presumption that nucleosomes are similar in resistance to MNase digestion. Using differential MNase digestion of chromatin and high-throughput sequencing, we have identified a special group of nucleosomes termed "fragile nucleosomes" throughout the yeast genome, nearly 1000 ...[more]