Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation.
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ABSTRACT:
SUBMITTER: Mizrachy-Schwartz S
PROVIDER: S-EPMC3083231 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation.
Mizrachy-Schwartz Sarit S Cohen Noam N Klein Shoshana S Kravchenko-Balasha Nataly N Levitzki Alexander A
The Journal of biological chemistry 20110118 17
We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells. ...[more]
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