Amyloid precursor protein is trafficked and secreted via synaptic vesicles.
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ABSTRACT:
SUBMITTER: Groemer TW
PROVIDER: S-EPMC3083403 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Amyloid precursor protein is trafficked and secreted via synaptic vesicles.
Groemer Teja W TW Thiel Cora S CS Holt Matthew M Riedel Dietmar D Hua Yunfeng Y Hüve Jana J Wilhelm Benjamin G BG Klingauf Jürgen J
PloS one 20110427 4
A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer's Disease (AD). Although APP processing and release are known to occur in response to neuronal stimulation, the exact mechanism by which APP reaches the neuronal surface is unclear. We now demonstrate that a small but relevant number of synaptic vesicles cont ...[more]
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