Ontology highlight
ABSTRACT:
SUBMITTER: Rice HC
PROVIDER: S-EPMC6366617 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Rice Heather C HC de Malmazet Daniel D Schreurs An A Frere Samuel S Van Molle Inge I Volkov Alexander N AN Creemers Eline E Vertkin Irena I Nys Julie J Ranaivoson Fanomezana M FM Comoletti Davide D Savas Jeffrey N JN Remaut Han H Balschun Detlef D Wierda Keimpe D KD Slutsky Inna I Farrow Karl K De Strooper Bart B de Wit Joris J
Science (New York, N.Y.) 20190101 6423
Amyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor for secreted APP (sAPP). Here we show that the sAPP extension domain directly bound the sushi 1 domain specific to the γ-aminobutyric acid type B receptor subunit 1a (GABA<sub>B</sub>R1a). sAPP-GABA<sub>B</sub>R1a binding suppressed synaptic transmission and ...[more]