Ontology highlight
ABSTRACT:
SUBMITTER: Flynn BJ
PROVIDER: S-EPMC3084061 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Flynn Barbara J BJ Kastenmüller Kathrin K Wille-Reece Ulrike U Tomaras Georgia D GD Alam Munir M Lindsay Ross W RW Salazar Andres M AM Perdiguero Beatriz B Gomez Carmen E CE Wagner Ralf R Esteban Mariano M Park Chae G CG Trumpfheller Christine C Keler Tibor T Pantaleo Giuseppe G Steinman Ralph M RM Seder Robert R
Proceedings of the National Academy of Sciences of the United States of America 20110405 17
Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune responses to HIV Gag p24 within 3G9 antibody to DEC205 ("DEC-HIV Gag p24"), an uptake receptor on dendritic cells, to nontargeted protein, with or without poly ICLC, a synthetic double stranded RNA, as adjuvant. Priming s.c. with 60 μg of both HIV Gag p24 vaccines elicited potent CD4(+) T cells secreting IL-2, IFN-γ, and TNF-α, which also ...[more]