Ontology highlight
ABSTRACT:
SUBMITTER: Romain G
PROVIDER: S-EPMC3649569 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Romain Gabrielle G van Gulck Ellen E Epaulard Olivier O Oh Sangkon S Li Dapeng D Zurawski Gerard G Zurawski Sandra S Cosma Antonio A Adam Lucille L Chapon Catherine C Todorova Biliana B Banchereau Jacques J Dereuddre-Bosquet Nathalie N Vanham Guido G Le Grand Roger R Martinon Frédéric F
European journal of immunology 20120704 8
The pivotal role of DCs in initiating immune responses led to their use as vaccine vectors. However, the relationship between DC subsets involved in antigen presentation and the type of elicited immune responses underlined the need for the characterization of the DCs generated in vitro. The phenotypes of tissue-derived APCs from a cynomolgus macaque model for human vaccine development were compared with ex vivo-derived DCs. Monocyte/macrophages predominated in bone marrow (BM) and blood. Myeloid ...[more]