Ontology highlight
ABSTRACT:
SUBMITTER: Tan DQ
PROVIDER: S-EPMC3084106 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Tan Darlene Q DQ Martin Kevin S KS Fettinger James C JC Shaw Jared T JT
Proceedings of the National Academy of Sciences of the United States of America 20110202 17
The synthesis of γ-lactams that are unsubstituted at the 1-position (nitrogen) as well as their subsequent N-functionalization is reported. A recently discovered four-component reaction (4CR) is employed with either an ammonia precursor or a protected form of ammonia that can be deprotected in a subsequent synthetic step. These methods represent the first multicomponent assembly of complex lactam structures that are unsubstituted at nitrogen. In addition, two methods for the introduction of nitr ...[more]