Ontology highlight
ABSTRACT:
SUBMITTER: Fenster E
PROVIDER: S-EPMC3511015 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20121019
A three-component method for the synthesis of γ-lactams from commercially available maleimides, aldehydes, and amines was adapted to parallel library synthesis. Improvements to the chemistry over previous efforts include the optimization of the method to a one-pot process, the management of by-products and excess reagents, the development of an automated parallel sequence, and the adaption of the method to permit the preparation of enantiomerically enriched products. These efforts culminated in ...[more]