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Design, synthesis, and biological evaluation of a biyouyanagin compound library.

ABSTRACT: Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted natural products, whose promising biological properties provide the motivation. Specifically, the present study targeted the naturally occurring biyouyanagins A and B and their analogs through modular chemical synthesis and led to the discovery of small organic molecules possessing anti-HIV and anti-arenavirus properties.

SUBMITTER: Nicolaou KC

PROVIDER: S-EPMC3084107 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Design, synthesis, and biological evaluation of a biyouyanagin compound library.

Nicolaou K C KC Sanchini Silvano S Sarlah David D Lu Gang G Wu T Robert TR Nomura Daniel K DK Cravatt Benjamin F BF Cubitt Beatrice B de la Torre Juan C JC Hessell Ann J AJ Burton Dennis R DR

Proceedings of the National Academy of Sciences of the United States of America 20110118 17

Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted natural products, whose promising biological properties provide the motivation. Specifically, the presen ...[more]

PMID: 21245351

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