Ontology highlight
ABSTRACT:
SUBMITTER: Linder T
PROVIDER: S-EPMC7038131 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200204 3
5-Methoxyleoligin and leoligin are natural occurring lignans derived from Edelweiss (<i>Leontopodium</i> <i>nivale</i> ssp<i>.</i> <i>alpinum</i>), displaying potent pro-angiogenic and pro-arteriogenic activity. Cholesterol efflux from macrophages is associated with reverse cholesterol transport which inhibits the development of cardiovascular disease. Within this study, we developed a modular and stereoselective total synthesis of 5-methoxyleoligin which can be readily used to prepare a novel c ...[more]