Ontology highlight
ABSTRACT:
SUBMITTER: Rossmanith W
PROVIDER: S-EPMC3084753 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20110429 4
RNase Z is an endonuclease responsible for the removal of 3' extensions from tRNA precursors, an essential step in tRNA biogenesis. Human cells contain a long form (RNase Z(L)) encoded by ELAC2, and a short form (RNase Z(S); ELAC1). We studied their subcellular localization by expression of proteins fused to green fluorescent protein. RNase Z(S) was found in the cytosol, whereas RNase Z(L) localized to the nucleus and mitochondria. We show that alternative translation initiation is responsible f ...[more]