Morphological differences between β(2) -microglobulin in fibrils and inclusion bodies.
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ABSTRACT:
SUBMITTER: Taylor GF
PROVIDER: S-EPMC3084992 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Morphological differences between β(2) -microglobulin in fibrils and inclusion bodies.
Taylor Garrick F GF Wood Stephen P SP Mörs Karsten K Glaubitz Clemens C Werner Jörn M JM Williamson Philip T F PT
Chembiochem : a European journal of chemical biology 20110126 4
Over expression of proteins in E. coli frequently results in the production of inclusion bodies. Although β(2) -microglobulin frequently forms fibrillar structures, our studies reveal significant differences between the protein in fibrils and inclusion bodies. This suggests that the formation of fibrils in inclusion bodies is dependent on the propensity of the protein to form fibrillar structures. ...[more]
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