Unknown

Dataset Information

0

MicroRNA gene dosage alterations and drug response in lung cancer.


ABSTRACT: Chemotherapy resistance is a key contributor to the dismal prognoses for lung cancer patients. While the majority of studies have focused on sequence mutations and expression changes in protein-coding genes, recent reports have suggested that microRNA (miRNA) expression changes also play an influential role in chemotherapy response. However, the role of genetic alterations at miRNA loci in the context of chemotherapy response has yet to be investigated. In this study, we demonstrate the application of an integrative, multidimensional approach in order to identify miRNAs that are associated with chemotherapeutic resistance and sensitivity utilizing publicly available drug response, miRNA loci copy number, miRNA expression, and mRNA expression data from independent resources. By instigating a logical stepwise strategy, we have identified specific miRNAs that are associated with resistance to several chemotherapeutic agents and provide a proof of principle demonstration of how these various databases may be exploited to derive relevant pharmacogenomic results.

SUBMITTER: Enfield KS 

PROVIDER: S-EPMC3085440 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

altmetric image

Publications

MicroRNA gene dosage alterations and drug response in lung cancer.

Enfield Katey S S KS   Stewart Greg L GL   Pikor Larissa A LA   Alvarez Carlos E CE   Lam Stephen S   Lam Wan L WL   Chari Raj R  

Journal of biomedicine & biotechnology 20110331


Chemotherapy resistance is a key contributor to the dismal prognoses for lung cancer patients. While the majority of studies have focused on sequence mutations and expression changes in protein-coding genes, recent reports have suggested that microRNA (miRNA) expression changes also play an influential role in chemotherapy response. However, the role of genetic alterations at miRNA loci in the context of chemotherapy response has yet to be investigated. In this study, we demonstrate the applicat  ...[more]

Similar Datasets

| S-EPMC5396474 | biostudies-literature
| S-ECPF-GEOD-48922 | biostudies-other
| S-EPMC3401360 | biostudies-literature
| S-EPMC7920352 | biostudies-literature
| S-EPMC3875770 | biostudies-literature
| S-EPMC8479169 | biostudies-literature
| S-EPMC3105413 | biostudies-literature
| S-EPMC2254495 | biostudies-literature
2018-03-08 | GSE93284 | GEO
| S-EPMC4320471 | biostudies-literature