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Alterations in bronchial airway microRNA expression for lung cancer detection

ABSTRACT: We have previously shown that gene-expression alterations in cytologically normal appearing bronchial epithelial cells can be used as a biomarker for lung cancer detection in smokers (Whitney et al., BMC Medical Genomics 2015; Silvestri et al., NEJM 2015). In this study, we have established that there are also alterations in bronchial microRNA-expression of smokers with lung cancer. Importantly, the performance of an existing bronchial mRNA-biomarker has been improved by integrating microRNA with mRNA expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93284 | GEO | 2018/03/08

REPOSITORIES: GEO

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