Ontology highlight
ABSTRACT:
SUBMITTER: Lehtinen MK
PROVIDER: S-EPMC3085909 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Lehtinen Maria K MK Zappaterra Mauro W MW Chen Xi X Yang Yawei J YJ Hill Anthony D AD Lun Melody M Maynard Thomas T Gonzalez Dilenny D Kim Seonhee S Ye Ping P D'Ercole A Joseph AJ Wong Eric T ET LaMantia Anthony S AS Walsh Christopher A CA
Neuron 20110301 5
Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood. Here, we show that the apical complex protein Pals1 and Pten have opposing roles in localizing the Igf1R to the apical, ventricular domain of cerebral cortical progenitor cells. We found that the cerebrospinal fluid (CSF), which contacts this apical domain, has an age-dependent effect on proliferation, much of which is attributable to Igf2, b ...[more]