Ontology highlight
ABSTRACT:
SUBMITTER: Kirby ED
PROVIDER: S-EPMC4386397 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kirby Elizabeth D ED Kuwahara Akela A AA Messer Reanna L RL Wyss-Coray Tony T
Proceedings of the National Academy of Sciences of the United States of America 20150316 13
The adult hippocampus hosts a population of neural stem and progenitor cells (NSPCs) that proliferates throughout the mammalian life span. To date, the new neurons derived from NSPCs have been the primary measure of their functional relevance. However, recent studies show that undifferentiated cells may shape their environment through secreted growth factors. Whether endogenous adult NSPCs secrete functionally relevant growth factors remains unclear. We show that adult hippocampal NSPCs secrete ...[more]