Ontology highlight
ABSTRACT:
SUBMITTER: Skasko M
PROVIDER: S-EPMC3086044 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Skasko Mark M Tokarev Andrey A Chen Cheng-Chang CC Fischer Wolfgang B WB Pillai Satish K SK Guatelli John J
Virology 20110114 1
Recent evidence suggests that transmembrane domain (TMD) interactions are essential for HIV-1 Vpu-mediated antagonism of the restriction factor BST-2/tetherin. We made Vpu TMD mutants to study the mechanism of BST-2 antagonism. Vpu-I17A, -A18F, -W22L, and -S23L co-localized with BST-2 within endosomal membranes while effectively enhancing virion release and down-regulating surface BST-2. However, Vpu-A18H was confined to an endoplasmic reticulum (ER)-like distribution, resulting in impaired down ...[more]