Ontology highlight
ABSTRACT:
SUBMITTER: Magadan JG
PROVIDER: S-EPMC2861688 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Magadán Javier G JG Pérez-Victoria F Javier FJ Sougrat Rachid R Ye Yihong Y Strebel Klaus K Bonifacino Juan S JS
PLoS pathogens 20100429 4
A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for proteasomal degradation. This function has been proposed to occur by a mechanism that is fundamentally distinct from the cellular ER-associated degradation (ERAD) pathway. However, using a combination of genetic, biochemical and morphological methodologies, we find that CD4 degradation induced by Vpu is dependent on a key component of the ERAD machinery, the VCP-UFD1L-NPL4 complex, as well as on SCF(beta-TrC ...[more]