PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.
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ABSTRACT:
SUBMITTER: Vanaja DK
PROVIDER: S-EPMC3086358 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.
Vanaja Donkena Krishna DK Grossmann Michael E ME Cheville John C JC Gazi Mozammel H MH Gong Aiyu A Zhang Jin San JS Ajtai Katalin K Burghardt Thomas P TP Young Charles Y F CY
Cancer investigation 20090301 3
We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These result ...[more]
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