Ontology highlight
ABSTRACT:
SUBMITTER: Haffner MC
PROVIDER: S-EPMC5529512 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Nature communications 20170726 1
A defining hallmark of primary and metastatic cancers is the migration and invasion of malignant cells. These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural components β-actin. Here we identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive properties in benign prostate epithelium. Depletion of AIM1 in prostate epithelial cells increases cytoskeletal remodeling, intracellular traction forces, cell migration a ...[more]