Ontology highlight
ABSTRACT:
SUBMITTER: Di Cello F
PROVIDER: S-EPMC3086547 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Di Cello Francescopaolo F Hillion Joelle J Hristov Alexandra A Wood Lisa J LJ Mukherjee Mita M Schuldenfrei Andrew A Kowalski Jeanne J Bhattacharya Raka R Ashfaq Raheela R Resar Linda M S LM
Molecular cancer research : MCR 20080501 5
Although previous studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined. The HMGA gene family includes HMGA1, which encodes the HMGA1a and HMGA1b protein isoforms, and HMGA2, which encodes HMGA2. These chromatin-binding proteins function in transcriptional regulation and recent studies also suggest a role in cellular senescence. HMGA1 proteins also appear to ...[more]