Ontology highlight
ABSTRACT:
SUBMITTER: Mayr C
PROVIDER: S-EPMC2556962 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Mayr Christine C Hemann Michael T MT Bartel David P DP
Science (New York, N.Y.) 20070222 5818
MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that can pair to sites within messenger RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA expression can contribute to tumorigenesis, but which of the many miRNA-target relationships are relevant to this process has been unclear. Here, we report that chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA. This disrupted repression ...[more]