Ontology highlight
ABSTRACT:
SUBMITTER: Jackman SL
PROVIDER: S-EPMC3086870 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Jackman Skyler L SL Babai Norbert N Chambers James J JJ Thoreson Wallace B WB Kramer Richard H RH
PLoS biology 20110503 5
Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. Cones transmit to HCs through an excitatory synapse and HCs feed back to cones through an inhibitory synapse. Here we report that HCs also transmit to cone terminals a positive feedback signal that elevates intracellular Ca(2+) and accelerates neurotransmitter release. Positive and negative feedback are both ...[more]