Ontology highlight
ABSTRACT:
SUBMITTER: Blanchard N
PROVIDER: S-EPMC3087292 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Blanchard Nicolas N Kanaseki Takayuki T Escobar Hernando H Delebecque Frédéric F Nagarajan Niranjana A NA Reyes-Vargas Eduardo E Crockett David K DK Raulet David H DH Delgado Julio C JC Shastri Nilabh N
Journal of immunology (Baltimore, Md. : 1950) 20100219 6
The MHC class I (MHC-I) molecules ferry a cargo of peptides to the cell surface as potential ligands for CD8(+) cytotoxic T cells. For nearly 20 years, the cargo has been described as a collection of short 8-9 mer peptides, whose length and sequences were believed to be primarily determined by the peptide-binding groove of MHC-I molecules. Yet the mechanisms for producing peptides of such optimal length and composition have remained unclear. In this study, using mass spectrometry, we determined ...[more]