Ontology highlight
ABSTRACT:
SUBMITTER: Matta JA
PROVIDER: S-EPMC3087383 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Matta Jose A JA Ashby Michael C MC Sanz-Clemente Antonio A Roche Katherine W KW Isaac John T R JT
Neuron 20110401 2
In cerebral cortex there is a developmental switch from NR2B- to NR2A-containing NMDA receptors (NMDARs) driven by activity and sensory experience. This subunit switch alters NMDAR function, influences synaptic plasticity, and its dysregulation is associated with neurological disorders. However, the mechanisms driving the subunit switch are not known. Here, we show in hippocampal CA1 pyramidal neurons that the NR2B to NR2A switch driven acutely by activity requires activation of NMDARs and mGluR ...[more]