Ontology highlight
ABSTRACT:
SUBMITTER: Fontan-Lozano A
PROVIDER: S-EPMC3180285 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Fontán-Lozano Ángela Á Suárez-Pereira Irene I González-Forero David D Carrión Angel Manuel AM
PloS one 20110926 9
Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The transient A-type K(+) current (I(A)) controls the excitability of the dendrites from CA1 pyramidal neurons by regulating the back-propagation of action potentials and shaping synaptic input. Here, we have studied how decreases in I(A) affect cognitive processes and synaptic plasticity. Using wild-type mice treated with 4-AP, an I(A) inhibitor, an ...[more]