Unknown

Dataset Information

0

The A-current modulates learning via NMDA receptors containing the NR2B subunit.


ABSTRACT: Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The transient A-type K(+) current (I(A)) controls the excitability of the dendrites from CA1 pyramidal neurons by regulating the back-propagation of action potentials and shaping synaptic input. Here, we have studied how decreases in I(A) affect cognitive processes and synaptic plasticity. Using wild-type mice treated with 4-AP, an I(A) inhibitor, and mice lacking the DREAM protein, a transcriptional repressor and modulator of the I(A), we demonstrate that impairment of I(A) decreases the stimulation threshold for learning and the induction of early-LTP. Hippocampal electrical recordings in both models revealed alterations in basal electrical oscillatory properties toward low-theta frequencies. In addition, we demonstrated that the facilitated learning induced by decreased I(A) requires the activation of NMDA receptors containing the NR2B subunit. Together, these findings point to a balance between the I(A) and the activity of NR2B-containing NMDA receptors in the regulation of learning.

SUBMITTER: Fontan-Lozano A 

PROVIDER: S-EPMC3180285 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

altmetric image

Publications

The A-current modulates learning via NMDA receptors containing the NR2B subunit.

Fontán-Lozano Ángela Á   Suárez-Pereira Irene I   González-Forero David D   Carrión Angel Manuel AM  

PloS one 20110926 9


Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The transient A-type K(+) current (I(A)) controls the excitability of the dendrites from CA1 pyramidal neurons by regulating the back-propagation of action potentials and shaping synaptic input. Here, we have studied how decreases in I(A) affect cognitive processes and synaptic plasticity. Using wild-type mice treated with 4-AP, an I(A) inhibitor, an  ...[more]

Similar Datasets

| S-EPMC4168240 | biostudies-literature
| S-EPMC6715386 | biostudies-literature
| S-EPMC9352834 | biostudies-literature
| S-EPMC3087383 | biostudies-literature
| S-EPMC6261414 | biostudies-literature
| S-EPMC3113701 | biostudies-literature
| S-EPMC6725198 | biostudies-literature
| S-EPMC6729941 | biostudies-literature
| S-EPMC1350965 | biostudies-literature
| S-EPMC6725474 | biostudies-literature