Ontology highlight
ABSTRACT:
SUBMITTER: Braskie MN
PROVIDER: S-EPMC3087508 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
International journal of Alzheimer's disease 20110331
Late onset Alzheimer's disease (AD) is moderately to highly heritable. Apolipoprotein E allele ε4 (APOE4) has been replicated consistently as an AD risk factor over many studies, and recently confirmed variants in other genes such as CLU, CR1, and PICALM each increase the lifetime risk of AD. However, much of the heritability of AD remains unexplained. AD is a complex disease that is diagnosed largely through neuropsychological testing, though neuroimaging measures may be more sensitive for dete ...[more]