Ontology highlight
ABSTRACT:
SUBMITTER: Cendron L
PROVIDER: S-EPMC3087634 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Cendron Laura L Veggi Daniele D Girardi Enrico E Zanotti Giuseppe G
Acta crystallographica. Section F, Structural biology and crystallization communications 20110420 Pt 5
fHbp, a highly immunogenic outer membrane protein of Neisseria meningitidis, is responsible for binding to human factor H, a multi-domain protein which is the central regulator of the alternative complement pathway. Here, the crystal structure of mature fHbp determined at 2 Å resolution is presented and is compared with the structure of the same protein in complex with factor H domains 6 and 7 recently solved using X-ray techniques. While the overall protein fold is well conserved, modifications ...[more]