Ontology highlight
ABSTRACT:
SUBMITTER: Krejci P
PROVIDER: S-EPMC3087869 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Krejci Pavel P Prochazkova Jirina J Smutny Jiri J Chlebova Katarina K Lin Patricia P Aklian Anie A Bryja Vitezslav V Kozubik Alois A Wilcox William R WR
Bone 20100331 1
Oncogenic activation of the RAS-ERK MAP kinase signaling pathway can lead to uncontrolled proliferation but can also result in apoptosis or premature cellular senescence, both regarded as natural protective barriers to cell immortalization and transformation. In FGFR3-related skeletal dyplasias, oncogenic mutations in the FGFR3 receptor tyrosine kinase cause profound inhibition of cartilage growth resulting in severe dwarfism, although many of the precise mechanisms of FGFR3 action remain unclea ...[more]