Ontology highlight
ABSTRACT:
SUBMITTER: Wong SM
PROVIDER: S-EPMC3088160 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Wong Sandy M S SM St Michael Frank F Cox Andrew A Ram Sanjay S Akerley Brian J BJ
Infection and immunity 20110228 5
Signaling mechanisms used by Haemophilus influenzae to adapt to conditions it encounters during stages of infection and pathogenesis are not well understood. The ArcAB two-component signal transduction system controls gene expression in response to respiratory conditions of growth and contributes to resistance to bactericidal effects of serum and to bloodstream infection by H. influenzae. We show that ArcA of nontypeable H. influenzae (NTHI) activates expression of a glycosyltransferase gene, li ...[more]