Ontology highlight
ABSTRACT:
SUBMITTER: Pankuch GA
PROVIDER: S-EPMC3088216 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Pankuch Glenn A GA Lin Gengrong G Kubo Aya A Armstrong Eliana S ES Appelbaum Peter C PC Kosowska-Shick Klaudia K
Antimicrobial agents and chemotherapy 20110131 5
ACHN-490 was tested alone and in combination with cefepime, doripenem, imipenem, or piperacillin-tazobactam in a synergy time-kill analysis against 25 Pseudomonas aeruginosa strains with different resistance phenotypes. Each combination was synergistic against most isolates at 24 h, and antagonism was not observed. Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-tazobactam yielded synergies in ≥70% and ≥80% of strains at 6 and 12 h, respectively, and in ≥68% at 24 h. ...[more]