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Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.

ABSTRACT: Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid.

SUBMITTER: Lin G

PROVIDER: S-EPMC2863652 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.

Lin Gengrong G Ednie Lois M LM Appelbaum Peter C PC

Antimicrobial agents and chemotherapy 20100209 5

Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid. ...[more]

PMID: 20145088

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