Ontology highlight
ABSTRACT:
SUBMITTER: Ahad AM
PROVIDER: S-EPMC3088502 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Ahad Ali Md AM Zuohe Song S Du-Cuny Lei L Moses Sylvestor A SA Zhou Li Li LL Zhang Shuxing S Powis Garth G Meuillet Emmanuelle J EJ Mash Eugene A EA
Bioorganic & medicinal chemistry 20110201 6
Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examine the effects of structural modification, a set of sulfonamides related to the lead compound was designed, synthesized, and tested for binding to the expressed PH domain of AKT using a surface plasmon ...[more]