Unknown

Dataset Information

0

Defining the origins of Ras/p53-mediated squamous cell carcinoma.

ABSTRACT: The precise identity of cancer cells of origin and the molecular events of tumor initiation in epidermal squamous cell carcinoma (SCC) are unknown. Here we show that malignancy potential is related to the developmental capacity of the initiating cancer cell in a genetically defined, intact, and inducible in vivo model. Specifically, these data demonstrate that SCCs can originate from inside the hair follicle stem cell (SC) niche or from immediate progenitors, whereas more developmentally restricted progeny, the transit amplifying (TA) cells, are unable to generate even benign tumors in the same genetic context. Using a temporal model of tumorigenesis in situ, we highlight the phenotypes of cancer progression from the hair follicle SC niche, including hyperplasia, epithelial to mesenchymal transition, and SCC formation. Furthermore, we provide insights into the inability of hair follicle TA cells to respond to tumorigenic stimuli.

SUBMITTER: White AC 

PROVIDER: S-EPMC3088581 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Defining the origins of Ras/p53-mediated squamous cell carcinoma.

White Andrew C AC   Tran Kathy K   Khuu Joan J   Dang Christine C   Cui Yongyan Y   Binder Scott W SW   Lowry William E WE  

Proceedings of the National Academy of Sciences of the United States of America 20110418 18

The precise identity of cancer cells of origin and the molecular events of tumor initiation in epidermal squamous cell carcinoma (SCC) are unknown. Here we show that malignancy potential is related to the developmental capacity of the initiating cancer cell in a genetically defined, intact, and inducible in vivo model. Specifically, these data demonstrate that SCCs can originate from inside the hair follicle stem cell (SC) niche or from immediate progenitors, whereas more developmentally restric  ...[more]

Similar Datasets

Unknown Defining Metabolic Rewiring in Lung Squamous Cell Carcinoma.
| S-EPMC6468359 | biostudies-literature
Unknown Prognostic Significance of RAS Mutations and P53 Expression in Cutaneous Squamous Cell Carcinomas.
| S-EPMC7397334 | biostudies-literature
Unknown RalA suppresses early stages of Ras-induced squamous cell carcinoma progression.
| S-EPMC2803332 | biostudies-literature
Unknown YY1 Promotes Telomerase Activity and Laryngeal Squamous Cell Carcinoma Progression Through Impairment of GAS5-Mediated p53 Stability.
| S-EPMC8421032 | biostudies-literature
Unknown p16, pRb, and p53 in Feline Oral Squamous Cell Carcinoma.
| S-EPMC5606583 | biostudies-literature
Unknown Defining the incidence of cutaneous squamous cell carcinoma in coastal NSW Australia.
| S-EPMC9321870 | biostudies-literature
Unknown Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?
| S-EPMC6160676 | biostudies-other
Unknown Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals.
| S-EPMC5762312 | biostudies-literature
Unknown PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation.
| S-EPMC5797815 | biostudies-other
Unknown Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells.
| S-EPMC3044990 | biostudies-literature