Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler K
PROVIDER: S-EPMC3088630 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Wheeler Karen K Tardif Steve S Rival Claudia C Luu Brian B Bui Elise E Del Rio Roxana R Teuscher Cory C Sparwasser Tim T Hardy Daniel D Tung Kenneth S K KS
Proceedings of the National Academy of Sciences of the United States of America 20110418 18
Vasectomy is a well accepted global contraceptive approach frequently associated with epididymal granuloma and sperm autoantibody formation. To understand the long-term sequelae of vasectomy, we investigated the early immune response in vasectomized mice. Vasectomy leads to rapid epithelial cell apoptosis and necrosis, persistent inflammation, and sperm granuloma formation in the epididymis. Vasectomized B6AF1 mice did not mount autoimmune response but instead developed sperm antigen-specific to ...[more]